After i apply all my skincare i use a cotton swab to wipe the pimple area down so that the patch can adhere better on the skin. I've also tried sticking the patch after toner and applying my skincare on top. After waking up i found that the patch had taken out the pus as the sticker had white stuff on it. The pimple was much flatter and cleared. I really like this product aswell as its almost transparent and i have a tendency to pick at my face but this prevents that. Highly recommend this product!