I use this after the Hydrium watery toner. Before I was using LRP dermallergo serum when I realised my skin barrier was damage but after finishing it, (at 20ml it didn't last long) my skin didn't feel any significant improvements.  This ampoule and the toner has changed all that.  Skin is less dry, dehydrated and less breakouts from sensitivity. Plus it's way more cost effective! My skin has gradually recovered after 2 months and I will repurchase :3.  I also use the ampoule to mix in TO 100% Niacinamide powder since the ampoule is a watery based serum.  The ampoule might seem like nothing special but for my skin it was a life saver due to the minimal non irritating ingredients.